[Testing of apathogenic influenza virus H5N3 as a poultry live vaccine].
Identifieur interne : 000497 ( Main/Exploration ); précédent : 000496; suivant : 000498[Testing of apathogenic influenza virus H5N3 as a poultry live vaccine].
Auteurs : E Y Boravleva ; I A Chvala ; N F Lomakina ; P I Repin ; N S Mudrak ; L G Rudenko ; A S Gambaryan ; V V DryginSource :
- Voprosy virusologii [ 0507-4088 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Grippe chez les oiseaux, Maladies de la volaille, Poulets, Vaccins antigrippaux, Vaccins atténués, Virus de la grippe A.
- virologie : Poulets.
- Animaux, Grippe chez les oiseaux, Maladies de la volaille, Souris.
English descriptors
- KwdEn :
- Animals, Chickens (immunology), Chickens (virology), Influenza A virus (immunology), Influenza Vaccines (immunology), Influenza in Birds (immunology), Influenza in Birds (prevention & control), Mice, Poultry Diseases (immunology), Poultry Diseases (prevention & control), Vaccines, Attenuated (immunology).
- MESH :
- chemical , immunology : Influenza Vaccines, Vaccines, Attenuated.
- immunology : Chickens, Influenza A virus, Influenza in Birds, Poultry Diseases.
- prevention & control : Influenza in Birds, Poultry Diseases.
- virology : Chickens.
- Animals, Mice.
Abstract
Four H5N2 experimental vaccine strains and the apathogenic wild duck H5N3 influenza virus A/duck/ Moscow/4182/2010 (dk/4182) were tested as a live poultry vaccine. Experimental strains had the hemagglutinin of the A/Vietnam/1203/04 strain lacking the polybasic HA cleavage site or the hemagglutinin from attenuated virus (Ku/ at) that was derived from the highly pathogenic influenza virus A/chicken/Kurgan/3/2005 (H5N1). The hemagglutinin of the Ku-at has the amino acid substitutions Asp54/Asn and Lys222/Thr in HA1 and Val48/Ile and Lys131/Thr in HA2, while maintaining the polybasic HA cleavage site at an invariable level. The other genes of these experimental strains were from the H2N2 cold-adapted master strain A/Leningrad/134/17/57 (VN-Len and Ku-Len) or from the apathogenic H6N2 virus A/gull/Moscow/3100/2006 (VN-Gull and Ku-Gull). A single immunization of mice with all tested strains elicited a high level of serum antibodies and provided complete protection against the challenge with the lethal dose of A/chicken/Kurgan/3/05. The pathogenicity indexes of the Ku-at and the other strains for chicken were virtually zero, whereas the index of the parent H5N1 virus A/chicken/Kurgan/3/2005 was 2.98. Intravenous, intranasal, and aerosol routes of vaccination were compared. It was shown that the strain dk/4182 was totally apathogenic for one-day-old chicken and provided complete protection against the highly pathogenic H5N1 virus.
PubMed: 26665435
Affiliations:
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Le document en format XML
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uniqKey="Gambaryan A" first="A S" last="Gambaryan">A S Gambaryan</name></author><author><name sortKey="Drygin, V V" sort="Drygin, V V" uniqKey="Drygin V" first="V V" last="Drygin">V V Drygin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26665435</idno><idno type="pmid">26665435</idno><idno type="wicri:Area/PubMed/Corpus">000057</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000057</idno><idno type="wicri:Area/PubMed/Curation">000057</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000057</idno><idno type="wicri:Area/PubMed/Checkpoint">000053</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000053</idno><idno type="wicri:Area/Ncbi/Merge">000C49</idno><idno type="wicri:Area/Ncbi/Curation">000C49</idno><idno type="wicri:Area/Ncbi/Checkpoint">000C49</idno><idno 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last="Mudrak">N S Mudrak</name></author><author><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L G" last="Rudenko">L G Rudenko</name></author><author><name sortKey="Gambaryan, A S" sort="Gambaryan, A S" uniqKey="Gambaryan A" first="A S" last="Gambaryan">A S Gambaryan</name></author><author><name sortKey="Drygin, V V" sort="Drygin, V V" uniqKey="Drygin V" first="V V" last="Drygin">V V Drygin</name></author></analytic><series><title level="j">Voprosy virusologii</title><idno type="ISSN">0507-4088</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Chickens (immunology)</term><term>Chickens (virology)</term><term>Influenza A virus (immunology)</term><term>Influenza Vaccines (immunology)</term><term>Influenza in Birds (immunology)</term><term>Influenza in Birds (prevention & control)</term><term>Mice</term><term>Poultry Diseases (immunology)</term><term>Poultry Diseases (prevention & control)</term><term>Vaccines, Attenuated (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Grippe chez les oiseaux ()</term><term>Grippe chez les oiseaux (immunologie)</term><term>Maladies de la volaille ()</term><term>Maladies de la volaille (immunologie)</term><term>Poulets (immunologie)</term><term>Poulets (virologie)</term><term>Souris</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins atténués (immunologie)</term><term>Virus de la grippe A (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe chez les oiseaux</term><term>Maladies de la volaille</term><term>Poulets</term><term>Vaccins antigrippaux</term><term>Vaccins atténués</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Chickens</term><term>Influenza A virus</term><term>Influenza in Birds</term><term>Poultry Diseases</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza in Birds</term><term>Poultry Diseases</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Poulets</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chickens</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Grippe chez les oiseaux</term><term>Maladies de la volaille</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Four H5N2 experimental vaccine strains and the apathogenic wild duck H5N3 influenza virus A/duck/ Moscow/4182/2010 (dk/4182) were tested as a live poultry vaccine. Experimental strains had the hemagglutinin of the A/Vietnam/1203/04 strain lacking the polybasic HA cleavage site or the hemagglutinin from attenuated virus (Ku/ at) that was derived from the highly pathogenic influenza virus A/chicken/Kurgan/3/2005 (H5N1). The hemagglutinin of the Ku-at has the amino acid substitutions Asp54/Asn and Lys222/Thr in HA1 and Val48/Ile and Lys131/Thr in HA2, while maintaining the polybasic HA cleavage site at an invariable level. The other genes of these experimental strains were from the H2N2 cold-adapted master strain A/Leningrad/134/17/57 (VN-Len and Ku-Len) or from the apathogenic H6N2 virus A/gull/Moscow/3100/2006 (VN-Gull and Ku-Gull). A single immunization of mice with all tested strains elicited a high level of serum antibodies and provided complete protection against the challenge with the lethal dose of A/chicken/Kurgan/3/05. The pathogenicity indexes of the Ku-at and the other strains for chicken were virtually zero, whereas the index of the parent H5N1 virus A/chicken/Kurgan/3/2005 was 2.98. Intravenous, intranasal, and aerosol routes of vaccination were compared. It was shown that the strain dk/4182 was totally apathogenic for one-day-old chicken and provided complete protection against the highly pathogenic H5N1 virus.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Boravleva, E Y" sort="Boravleva, E Y" uniqKey="Boravleva E" first="E Y" last="Boravleva">E Y Boravleva</name><name sortKey="Chvala, I A" sort="Chvala, I A" uniqKey="Chvala I" first="I A" last="Chvala">I A Chvala</name><name sortKey="Drygin, V V" sort="Drygin, V V" uniqKey="Drygin V" first="V V" last="Drygin">V V Drygin</name><name sortKey="Gambaryan, A S" sort="Gambaryan, A S" uniqKey="Gambaryan A" first="A S" last="Gambaryan">A S Gambaryan</name><name sortKey="Lomakina, N F" sort="Lomakina, N F" uniqKey="Lomakina N" first="N F" last="Lomakina">N F Lomakina</name><name sortKey="Mudrak, N S" sort="Mudrak, N S" uniqKey="Mudrak N" first="N S" last="Mudrak">N S Mudrak</name><name sortKey="Repin, P I" sort="Repin, P I" uniqKey="Repin P" first="P I" last="Repin">P I Repin</name><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L G" last="Rudenko">L G Rudenko</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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